Memantin HCl

5000.00 - 50000.00 INR/Kilograms

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Product Details:

Molecular Formula C12H21N.HCl
Storage Other
Shelf Life 5 Years
Medicine Name Memantin HCl
CAS No 41100-52-1
Type Pharmaceutical Intermediates
Grade Medicine Grade
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Product Description

Memantin HCl Price And Quantity

Price Range 5000.00 - 50000.00 INR/Kilograms
Minimum Order Quantity 25 Kilograms

Memantin HCl Product Specifications

CAS No 41100-52-1
Molecular Formula C12H21N.HCl
Shelf Life 5 Years
Physical Form Powder
Storage Other
Grade Medicine Grade
Purity(%) 99
Usage Central Nervous System Agent
Medicine Name Memantin HCl
Type Pharmaceutical Intermediates
Appearance White powder

Memantin HCl Trade Information

FOB Port MUMBAI
Payment Terms Western Union Paypal Cash Advance (CA) Cash in Advance (CID)
Supply Ability 500 Kilograms Per Week
Delivery Time 15 Days
Packaging Details 25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.
Main Export Market(s) Australia Central America South America Western Europe Middle East Eastern Europe Asia North America Africa
Main Domestic Market All India

Product Description

A dysfunction of glutamatergic neurotransmission, manifested as neuronal excitotoxicity, is hypothesized to be involved in the etiology of Alzheimer's disease. Targeting the glutamatergic system, specifically NMDA receptors, offers a novel approach to treatment in view of the limited efficacy of existing drugs targeting the cholinergic system.

Memantine is a low-affinity voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptors. By binding to the NMDA receptor with a higher affinity than Mg2+ ions, memantine is able to inhibit the prolonged influx of Ca2+ ions which forms the basis of neuronal excitotoxicity. The low affinity and rapid off-rate kinetics of memantine at the level of the NMDA receptor-channel, however, preserves the physiological function of the receptor as it can still be activated by the relatively high concentrations of glutamate released following depolarization of the presynaptic neuron.

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